Probiotics in food are a kind of living bacteria that are beneficial to human health and are closely related to human health. Prebiotics are beneficial bacteria foods that promote the growth and activity of some beneficial bacteria, thereby improving the health of the human gut. It is the energy source of beneficial bacteria in the intestine.
The incidence of intestinal diseases in China has increased year by year. Clinical studies show that there is a serious intestinal flora imbalance in these patients. By giving probiotics to adjust the local micro-ecological environment, the disease can be alleviated.
Probiotics are a class of non-pathogenic microorganisms that have a positive effect on the health and physiological functions of the host when digested.
The intestinal flora is a major component of the intestinal mucosal barrier and plays an important physiological role in maintaining intestinal function and health. Gastrointestinal dysfunction, including dysbacteriosis, constipation, and gastric mucosal damage are common clinical complications and are a type of disease with a high incidence and a wide range of patients in modern lifestyles.
Lactobacillus and Bifidobacteria are the main organs of intestinal beneficial bacteria and are an important part of the intestinal biological barrier, which is closely related to the maintenance of immunity, nutrition and normal functions of the gastrointestinal tract.
Microecology uses the theory of "bacterial treatment of bacteria" to correct the micro-ecological imbalance through biological antagonism. It is an important supplement to therapeutic medicine and preventive medicine. It is a brand-new therapeutic concept that can not only avoid the side effects of the above antibiotic application but also the preliminary research in clinical practice has received a very positive effect, which has great potential for development and can be a new measure to prevent intestinal infection.
At present, the existing microecological preparations in China have many problems such as single formulation and unstable efficacy, which limits the application and development of microecological preparations. Therefore, this study intends to screen a good performance Lactobacillus, and rational compatibility with prebiotics, to form a synbiotic formula, through animal experiments to verify its regulation of the gastrointestinal tract, including the regulation of intestinal flora, It has a laxative effect and an auxiliary protective effect on gastric mucosal damage; and it is made into a novel micro-ecological preparation with stable performance by using advanced freeze-drying process, so that it can fully exert its regulating effect on the gastrointestinal tract.
In recent years, with the rise of people's living standards and changes in dietary structure, the incidence of intestinal diseases in China has increased year by year.
Probiotics are a class of non-pathogenic microorganisms that have a positive effect on the health and physiological functions of the host when digested. They consist of yeasts and bacteria, especially lactic acid bacteria, whose fate and effects in the intestine vary from strain to strain.
The action of probiotics can be achieved directly or indirectly by modulating the endogenous flora or immune system. Although the use of probiotics also reduces the effects of other diseases, it is often used to treat gastrointestinal-related diseases. Nonetheless, only a few probiotic strains were considered to be beneficial in randomized, placebo-controlled clinical trials.
Probiotics treat human gastrointestinal diseases. For example, acute gastroenteritis, lactose intolerance, inflammatory bowel disease, antibiotic diarrhea,
Constipation, traveler's diarrhea, colorectal cancer, etc. In this paper, the current application of probiotics in the treatment of human gastrointestinal diseases, the practical application of lactose intolerance as an example:
Lactose intolerance: or more accurately referred to as lactose intolerance, is caused by less production of a-galactosidase.
It mainly occurs in adults (primary lactose dyspepsia) and intestinal resection or patients with enteritis (secondary lactose dyspepsia). Primary lactose dyspepsia is normal in all adult mammals except those of Northwestern European descent.
In 1984, KOLARS used the respiratory hydrogen test (a common method for determining lactose digestion and absorption) to prove that lactose indigestion is more tolerant and digestible to lactose in yogurt than raw milk. In 1987, this result was confirmed by DEWIT et al. Also, he also found that the intake of yogurt or heated yogurt restored the insulin secretion of lactose indigestion to the control level, while the fresh intake of heated yogurt increased free. Absorption of fatty acids. Extensive investigation of its mechanism found that the survival of lactic acid bacteria is important because pasteurization reduces the digestibility of fermented milk.
There are at least two mechanisms that are not mutually exclusive:
(1)A-galactosidase is present in the bacteria involved in the milk fermentation, and the bacteria are dissolved in the small intestine by the bile during digestion, and the enzyme is released to degrade the lactose. Compared to raw milk, the concentration of lactose in yogurt decreased by 30%. The poor performance of pasteurized products may be due to decreased activity of live bacteria and/or lactase.
(2)Nevertheless, some researchers believe that the presence of bacterial lactase may not be the only explanation for the improvement in lactose uptake. Due to the buffering effect of yogurt, the pH observed in the duodenum is 5.0, at which time the α-galactosidase activity is reduced by 80%.
A recent clinical study suggests that bacterial lactase may not be as important as previously mentioned. Another explanation is that the fermented milk has high viscosity and makes it pass through the gastrointestinal tract for a long time, which is beneficial to the contact of residual lactase on the intestinal cells with lactose in the intestinal lumen.
Further help the digestion of lactose. Other scholars have confirmed this possibility when conducting studies on children and adults with lactose indigestion.
Counting trillions of bacteria in the human intestines control the intestinal environment. Different microflora has different effects on the human body. The harmful bacteria and beneficial bacteria are interdependent and mutually restrictive in the case of human health. The flora is balanced and the structure is stable. The performance is that the number of beneficial bacteria in the intestine is dominant. The mucosa is pink and the intestines are relatively healthy. Beneficial bacteria are also called probiotics, including Bifidobacteria, Lactobacillus and other strains. They can synthesize vitamins that are indispensable to the human body, promote the absorption of nutrients and intestinal peristalsis, and inhibit harmful bacteria and decompose toxic and harmful substances.
Many people suffer from nausea, abdominal pain, flatulence, and diarrhea after eating foods containing lactose. Foods that may contain lactose include snacks such as milk, baked goods, processed breakfast cereals, luncheon meat, and biscuits. Probiotics and harmful bacteria are all based on lactose, but when the intestinal flora is dysregulated, only a small number of probiotics have a large number of harmful bacteria, harmful bacteria will generate gas, swallowing a large amount of lactose to cause flatulence, causing abdominal pain, most of which People have experience.
And if the probiotics can't help the body to digest a certain amount of lactose, lactose will quickly enter the colon through the gastrointestinal tract. The colon is the part that absorbs water and electrolytes during digestion. Excessive lactose, water can not be absorbed, it will lead to diarrhea.
Most of the manifestations of intestinal flora imbalance are symptoms that are easily overlooked, but the resulting diseases can have disastrous consequences for health. Restoring the balance of intestinal flora, in addition to eating healthy, health, exercise, but also to add enough probiotics, the presence of a large number of probiotics in the intestines, can quickly occupy the position, re-occupy the gastrointestinal tract, inhibit and eliminate harmful bacteria. The key to taking probiotics depends on the activity. The more probiotics, the better, because each probiotic will have a different effect on the stomach.